If you’re looking for the best ATS wager to make among the 16 NFL matchups in Week 2, we’re on the Giants at +1.5. Don’t stop there, though — scroll down, because we have plenty more tips, which you could take advantage of in a parlay.

NFL Picks Against the Spread – Week 2

Jump to Matchup:

Pick: Giants +1.5 vs. Commanders

• Matchup: New York Giants at Washington Commanders
• Projected Winner & Margin: Giants by 11.0 points (Bet on this game at BetMGM)
• Spread: Commanders -1.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Rams +1.5 vs. Cardinals

• Matchup: Los Angeles Rams at Arizona Cardinals
• Projected Winner & Margin: Rams by 11.0 points (Bet on this game at BetMGM)
• Spread: Cardinals -1.5
• Time: 4:05 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Dolphins -2.5 vs. Bills

• Matchup: Buffalo Bills at Miami Dolphins
• Projected Winner & Margin: Dolphins by 3.0 points (Bet on this game at BetMGM)
• Spread: Dolphins -2.5
• Time: 8:15 PM ET
• Date: Sept. 12
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Browns +3 vs. Jaguars

• Matchup: Cleveland Browns at Jacksonville Jaguars
• Projected Winner & Margin: Browns by 4.0 points (Bet on this game at BetMGM)
• Spread: Jaguars -3
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Broncos

• Matchup: Pittsburgh Steelers at Denver Broncos
• Projected Winner & Margin: Steelers by 15.0 points (Bet on this game at BetMGM)
• Spread: Steelers -3
• Time: 4:25 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Titans +3.5 vs. Jets

• Matchup: New York Jets at Tennessee Titans
• Projected Winner & Margin: Titans by 6.0 points (Bet on this game at BetMGM)
• Spread: Jets -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Colts -3.5 vs. Packers

• Matchup: Indianapolis Colts at Green Bay Packers
• Projected Winner & Margin: Colts by 4.0 points (Bet on this game at BetMGM)
• Spread: Colts -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Patriots +3.5 vs. Seahawks

• Matchup: Seattle Seahawks at New England Patriots
• Projected Winner & Margin: Patriots by 13.0 points (Bet on this game at BetMGM)
• Spread: Seahawks -3.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +6 vs. 49ers

• Matchup: San Francisco 49ers at Minnesota Vikings
• Projected Winner & Margin: Vikings by 28.0 points (Bet on this game at BetMGM)
• Spread: 49ers -6
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bengals +6 vs. Chiefs

• Matchup: Cincinnati Bengals at Kansas City Chiefs
• Projected Winner & Margin: Chiefs by 3.0 points (Bet on this game at BetMGM)
• Spread: Chiefs -6
• Time: 4:25 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys -6.5 vs. Saints

• Matchup: New Orleans Saints at Dallas Cowboys
• Projected Winner & Margin: Cowboys by 22.0 points (Bet on this game at BetMGM)
• Spread: Cowboys -6.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers -6.5 vs. Panthers

• Matchup: Los Angeles Chargers at Carolina Panthers
• Projected Winner & Margin: Chargers by 23.2 points (Bet on this game at BetMGM)
• Spread: Chargers -6.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons +6.5 vs. Eagles

• Matchup: Atlanta Falcons at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 3.0 points (Bet on this game at BetMGM)
• Spread: Eagles -6.5
• Time: 8:15 PM ET
• Date: Sept. 16
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers +7 vs. Lions

• Matchup: Tampa Bay Buccaneers at Detroit Lions
• Projected Winner & Margin: Lions by 3.0 points (Bet on this game at BetMGM)
• Spread: Lions -7
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans -7 vs. Bears

• Matchup: Chicago Bears at Houston Texans
• Projected Winner & Margin: Texans by 13.0 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 8:20 PM ET
• Date: Sept. 15
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Raiders +9.5 vs. Ravens

• Matchup: Las Vegas Raiders at Baltimore Ravens
• Projected Winner & Margin: Ravens by 5.0 points (Bet on this game at BetMGM)
• Spread: Ravens -9.5
• Time: 1:00 PM ET
• Date: Sept. 15
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.