After studying the 13 matchups on the Week 12 card in the NFL, our best against-the-spread choice is Cardinals -1. For more suggestions, which could lead to parlay opportunities, continue reading.

NFL Picks Against the Spread – Week 12

Jump to Matchup:

Pick: Cardinals -1 vs. Seahawks

• Matchup: Arizona Cardinals at Seattle Seahawks
• Projected Winner & Margin: Cardinals by 3.1 points (Bet on this game at BetMGM)
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -2.5 vs. 49ers

• Matchup: San Francisco 49ers at Green Bay Packers
• Projected Winner & Margin: Packers by 9.3 points (Bet on this game at BetMGM)
• Spread: Packers -2.5
• Time: 4:25 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Eagles -3 vs. Rams

• Matchup: Philadelphia Eagles at Los Angeles Rams
• Projected Winner & Margin: Eagles by 3.5 points (Bet on this game at BetMGM)
• Spread: Eagles -3
• Time: 8:20 p.m. ET
• Date: Nov. 24
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chargers +3 vs. Ravens

• Matchup: Baltimore Ravens at Los Angeles Chargers
• Projected Winner & Margin: Chargers by 2.3 points (Bet on this game at BetMGM)
• Spread: Ravens -3
• Time: 8:15 p.m. ET
• Date: Nov. 25
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -3.5 vs. Browns

• Matchup: Pittsburgh Steelers at Cleveland Browns
• Projected Winner & Margin: Steelers by 16.4 points (Bet on this game at BetMGM)
• Spread: Steelers -3.5
• Time: 8:15 p.m. ET
• Date: Nov. 21
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Vikings -3.5 vs. Bears

• Matchup: Minnesota Vikings at Chicago Bears
• Projected Winner & Margin: Vikings by 10.1 points (Bet on this game at BetMGM)
• Spread: Vikings -3.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Buccaneers -5.5 vs. Giants

• Matchup: Tampa Bay Buccaneers at New York Giants
• Projected Winner & Margin: Buccaneers by 11.3 points (Bet on this game at BetMGM)
• Spread: Buccaneers -5.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos -5.5 vs. Raiders

• Matchup: Denver Broncos at Las Vegas Raiders
• Projected Winner & Margin: Broncos by 11.7 points (Bet on this game at BetMGM)
• Spread: Broncos -5.5
• Time: 4:05 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Patriots +7 vs. Dolphins

• Matchup: New England Patriots at Miami Dolphins
• Projected Winner & Margin: Dolphins by 5.6 points (Bet on this game at BetMGM)
• Spread: Dolphins -7
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Lions -7.5 vs. Colts

• Matchup: Detroit Lions at Indianapolis Colts
• Projected Winner & Margin: Lions by 12.2 points (Bet on this game at BetMGM)
• Spread: Lions -7.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Texans -8.5 vs. Titans

• Matchup: Tennessee Titans at Houston Texans
• Projected Winner & Margin: Texans by 16.6 points (Bet on this game at BetMGM)
• Spread: Texans -8.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Commanders -10.5 vs. Cowboys

• Matchup: Dallas Cowboys at Washington Commanders
• Projected Winner & Margin: Commanders by 18.0 points (Bet on this game at BetMGM)
• Spread: Commanders -10.5
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Chiefs -11 vs. Panthers

• Matchup: Kansas City Chiefs at Carolina Panthers
• Projected Winner & Margin: Chiefs by 20.3 points (Bet on this game at BetMGM)
• Spread: Chiefs -11
• Time: 1 p.m. ET
• Date: Nov. 24
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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